Liu et al. reported that a transferrin-conjugated nanoparticle system efficiently delivered synthesized miR-29b mimics to AML blasts and improved the antileukemic activity of decitabine by priming AML cells through downregulation of DNMTs, CDK6, SP1, KIT, and FLT3 genes, which are frequently overexpressed or mutated in AML16. Here, CDK6 is linked to acute myeloid leukemia.