An earlier study by Chen et al. reported that ectopic expression of Pdx1, MafA, and Neurog3 in the intestinal crypts results in their conversion into cells with β-like feature called “neoislets”, and importantly, intestinal neoislets are glucose-responsive and able to ameliorate hyperglycemia in STZ-induced diabetic mice. Here, PDX1 is linked to Hyperglycemia.