Nevertheless, our data suggest that reduced BRD7 levels play a role in the progression of obesity and hyperglycemia. Furthermore, here we clearly show that sustained overexpression of BRD7 levels in the liver of HFD-induced obese mice by AAV-mediated gene transfer system prevents excessive weight gain, significantly decreases blood glucose levels, and improves glucose metabolism. This evidence concerns the gene BRD7 and obesity due to melanocortin 4 receptor deficiency.