BRD7 and obesity due to melanocortin 4 receptor deficiency: Given that our BRD7+/− and LBKO mice displayed increased weight gain and BRD7 upregulation significantly improved glucose homeostasis in AAV-Cre-injected BRD7 Tg+/− mice, we sought to investigate whether the early upregulation of BRD7 could also protect against the development of obesity.