In addition to the cDC-exclusion effect of melanoma cell-intrinsic b-catenin activation, paracrine Wnt5a signaling from melanoma cells to DCs leads to b-catenin activation, tolerogenic gene transcription, as well as fatty acid oxidation and post-translational activation of the immunosuppressive enzyme indoleamine (IDO)11–14. Here, WNT5A is linked to melanoma.