Along with the fact that Wnt1 overexpression shifted the profile of adoptively transferred OTI T cells towards hypoproliferative, tolerogenic and exhausted and that we observed lower numbers of intratumoral OTI T cells and impaired cytotoxicity against OVA-LLC cells, these results strongly support the proposal that Wnt1 enables immunogenic tumors evade cross-priming of cancer antigen-specific CD8+ T cells and turns tumors immunologically cold. Here, CD8A is linked to cancer.