Similarly, IL-17-rich cytokine profiles were observed in antigen-restricted CD4+ T cells co-cultured with antigen-pulsed PDATME DC that were harvested from both autochthonous P48Cre;KrasG12D (KC) and Pdx1Cre;KrasG12D;Tp53R172H (KPC) mouse PDA tumors, suggesting these observations are not specific to the orthotopic PDA model (Supplementary Figure 2G, H). This evidence concerns the gene CALCA and Patent ductus arteriosus.