CD4 and Patent ductus arteriosus: Moreover, DC depletion in vivo lowered tumor-infiltrating CD4+ T-cell expression of CD39, CD49b, CD73, AHR, IL-17, and IL-10 in PDA suggesting that, besides driving select cytokine expression, DC promote this Tr1-like surface phenotype in PDA-associated CD4+ T cells (Fig. 5e).