Overall, this strongly indicates that the IGK-CCNG1 translocation occurred earlier (at the pre-B or immature B-cell stage) in the evolution of this tumor than the IGH-MYC translocation (at the germinal center stage) showing that IG-MYC translocations might not always be the initial genetic event in BL (Fig. 3c). The gene discussed is MYC; the disease is neoplasm.