To investigate IL-8 expression patterns across different tumor compartments, we utilized the Ivy Glioblastoma Atlas Project (IVY GAP)14, which demonstrated that IL-8 mRNA is elevated in pseudopalisading cells and the perinecrotic zone, two areas linked to the GIC subpopulation (Fig. 2f). The gene discussed is CXCL8; the disease is glioblastoma.