Further, the expression of macrophage growth factors, CSF1, CSF2, and IL34, were higher at the CKD phase in CCR2−/− kidneys compared to WT (Fig. 2d), which suggests a formation of a pro-proliferative micro-environment for macrophages in CCR2−/− kidneys after I/R injury. The gene discussed is CCR2; the disease is chronic kidney disease.