In addition, complement C5a receptor 1 (C5ar1) and complement C5a receptor 2 (C5ar2), which have recently been identified to be linked to AKI-CKD progression35, were upregulated in CCR2−/− kidneys at day 30 after I/R compared to WT mice (Supplementary Fig. 1). The gene discussed is C5AR2; the disease is chronic kidney disease.