PRF1 and neoplasm: The microarray data revealed 728 distinctly regulated genes between two populations and the top highly expressed genes (IL2RB, GZMA, GZMB, EMR4, PRF1, CX3CR1, STAT1, and TLR9) in lung-derived Ly6C+ cells from EMT6 tumor-bearing mice are associated with effector T-cell function (Fig. 6b, c and Supplementary Data 1).