Finally, eleven CpG sites were associated with metabolic syndrome: cg08862778 (MTOR), cg11322849 (INS), cg07199894 (ULK1), cg11658986-cg04149773 (ADCY6), cg14862787-11301281 (CREB5), cg14844401-cg20300093 (ADCY5), cg01284192 (IGF1R) and cg08128650 (RELA) (Figure 4). The gene discussed is ADCY5; the disease is metabolic syndrome.