In liver biopsies, two CpG sites (cg15283498-FOXO3; cg07012178-PRKAG2) were hypomethylated, whereas in subcutaneous adipose tissue from subjects with or without metabolic syndrome, cg07340599 (CREB5) and cg08779982 (TSC2) were hypomethylated. The gene discussed is TSC2; the disease is metabolic syndrome.