IRS1 and Insulin resistance: In the case of IRS1 (cg21511036), AKT1S1 (cg03813033), ADCY2 (cg12566890 and EHMT2 (cg00210002) are hypomethylated, whereas AKT1 (cg01749142), FOXO3 (15283498), are hypermethylated in subjects with insulin resistance and hypertriglyceridemia.