Thirteen CpG were positively associated with hypercholesterolemia: cg08862778 (MTOR), cg07199894 (ULK1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg06223834 (ADCY9), cg18237616 (RHEB), cg05792022 (FOXO1), cg01781374 (CAMK4), cg11301281 (CREB5), cg14267811 (TSC1), cg08128650 (RELA), cg01284192 (IGF1R), cg24061580 (PRKAG2) (Figure 2). The gene discussed is RHEB; the disease is Hypercholesterolemia.