IRS1 and Hyperglycemia: In the old sub-population, from the 14 CpG sites that were associated with BMI in Table 7, we observed that three CpG sites were hypomethylated in hyperglycemia (cg13551841, cg08779982, cg21511036), two CpG sites were hypomethylated (cg13551841 and cg21511036) and one CpG residing in ADIPOR1 (cg04566392) was hypermethylated in insulin resistance, and the CpG residing in IRS1 (cg21511036) was hypomethylated in subjects with hypertriglyceridemia (Table 8).