In the case of IRS1 (cg21511036), AKT1S1 (cg03813033), ADCY2 (cg12566890 and EHMT2 (cg00210002) are hypomethylated, whereas AKT1 (cg01749142), FOXO3 (15283498), are hypermethylated in subjects with insulin resistance and hypertriglyceridemia. The gene discussed is AKT1S1; the disease is hypertriglyceridemia.