There were no significant changes in the M-oe-CDKN2B-AS1 + oe-ADAM10 group, indicating that overexpression of CDKN2B-AS1 inhibited atherosclerosis, overexpression of ADAM10 promoted atherosclerosis, and overexpression of CDKN2B-AS1 can reverse the effect of ADAM10 on atherosclerosis. The gene discussed is ADAM10; the disease is atherosclerosis.