The overexpression of CDKN2B-AS1 during the current study was observed to result in a decreased in the expression of ADAM10 while the restoration of ADAM10 reversed the CDKN2B-AS1-induced inhibition effects on the levels of TC, TG and LDL, indicating that CDKN2B-AS1 could inhibit atherosclerosis by inhibiting the expression of ADAM10. The gene discussed is CDKN2B; the disease is atherosclerosis.