No significant changes in relation to the serum levels of IL-1β and TNF-ɑ in the M-oe-CDKN2B-AS1 + oe-ADAM10 group were detected, highlighting the inhibitory role of CDKN2B-AS1 in the stimulating effect of ADAM10 on the inflammatory response associated with atherosclerosis. The gene discussed is TNF; the disease is atherosclerosis.