ADAM10 group exhibited no significant changes regarding atherosclerotic lesions, indicating that overexpression of CDKN2B-AS1 inhibited atherosclerotic lesions, overexpression of ADAM10 promoted atherosclerosis in sclerotic lesions, while the overexpression of CDKN2B-AS1 reversed the effects of ADAM10 on atherosclerotic lesions. This evidence concerns the gene CDKN2B and atherosclerosis.