They further demonstrated that hypoxia-induced recruitment of α6β4 integrin toward exosomal C4.4A, MMP-14 membrane type 1 matrix metalloproteinase/MT1-MMP), and TACE (tumor necrosis factor-α-converting enzyme) allows for a shift from adhesion to motility of recipient tumor cells [49]. This evidence concerns the gene MMP14 and neoplasm.