In vitro and in vivo studies with PCa cell lines suggest that alterations in CXCR7/RDC1, receptor for SDF-1/CXCL12, are associated with enhanced adhesive and invasive activities, regulates the expression of the proangiogenic factors IL-8 or vascular endothelial growth factor, which are likely to participate in the regulation of tumor angiogenesis [70]. Here, ACKR3 is linked to neoplasm.