A new study disclosed that exposure of granulocytic HL-60 cells to EVs from oncogenic HRAS-driven cancer cells is responsible for a selective increase in TF pro-coagulant activity and interleukin 8 (IL-8) production, suggesting that these cells may represent a hitherto unrecognized reservoir of cancer-derived, EV-associated oncogenic genomic DNA in the circulation, and a potential novel platform for liquid biopsy in cancer clinics [17]. This evidence concerns the gene CXCL8 and cancer.