A study analyzing exosomes derived from cancer-associated fibroblasts (CAFs) in oral squamous cell carcinoma (OSCC) unveiled that the miR-34a-5p/AXL axis can enhance OSCC progression via the AKT/GSK-3β/β-catenin signaling pathway, which induces the epithelial-mesenchymal-transition (EMT) to promote cancer cell growth and subsequent metastasis [21]. This evidence concerns the gene GSK3B and cancer.