TP53 and cancer: In addition, the levels of cell-associated and circulating EV-carried tissue factor (TF, a primary cellular initiator of blood coagulation and a regulator of angiogenesis and metastasis) are correlated with the genetic status of cancer cells, such as an activated KRAS oncogene or a loss-of-function mutation of the p53 tumor suppressor, suggesting a causal link between cancer-associated coagulopathy, angiogenesis and malignant progression [16].