For instance, MVs produced by human cancer cells harboring activated EGFR can be absorbed by cultured endothelial cells which subsequently exhibit EGFR-dependent responses including activation of MAPK and Akt pathways, while the intercellular EGFR transfer is accompanied by the onset of VEGF expression in these endothelial cells and autocrine activation of VEGF receptor-2 [15]. Here, EGFR is linked to cancer.