In contrast, exosomes from pancreatic cancer cells activate various gene expression in HUVECs, promote phosphorylation of Akt and ERK1/2 signaling molecules and tube formation via dynamin-dependent endocytosis, suggesting that pancreatic cancer cell-released exosomes may act as a novel angiogenesis stimulator [86]. Here, AKT1 is linked to familial pancreatic carcinoma.