PVT1 and cancer: The plasmacytoma variant translocation 1 (Pvt1) gene was initially identified as a transcriptional unit encoded by a sequence homologous to the PVT1 gene, and Pvt1 promoted cell proliferation and cell cycle progression and inhibited apoptosis when overexpressed and amplified in a variety of cancers, indicating that it is an oncogene [26, 39, 40].