B4GALT3 and hepatocellular carcinoma: For example, high-metastatic hepatocellular carcinoma cells release exosomes containing miR-1247-3p that target B4GALT3 and activate beta1-integrin-NF-kappaB signaling in fibroblasts, further boosting cancer progression by releasing pro-inflammatory cytokines, including IL-6 and IL-8 [52].