In addition, a recent study has revealed the mechanisms responsible for the lung metastasis of liver cancer: High-metastatic hepatocellular carcinoma cells can release exosomes containing miR-1247-3p to activate fibroblasts by targeting B4GALT3, and these activated fibroblasts can then release pro-inflammatory factors to boost lung metastasis [52]; this study has revealed a new molecular mechanism underlying the interaction between exosomal miRNAs and fibroblasts to promote lung metastasis. Here, B4GALT3 is linked to hepatocellular carcinoma.