The presence of selective P-gp/MDR-1 mRNA in EVs released from doxorubicin-resistant osteosarcoma cells suggests that resistant tumor cells use several means to spread drug resistance to sensitive cells, either by transferring MDR proteins directly to sensitive cells or by transferring the mRNA that encodes them, contributing to the diversity of drug resistance mechanisms [100]. This evidence concerns the gene PGP and osteosarcoma.