For example, miR-9 contained in EVs promotes tumor angiogenesis and endothelial cells migration through the reduction of suppressor of cytokine signaling 5 (SOCS5) levels and the activation of the JAK/STAT pathway [48], while EVs carrying miR-23a are capable of inducing angiogenesis in different angiogenic model systems by targeting SIRT1 in recipient endothelial cells [49]. The gene discussed is SOCS5; the disease is neoplasm.