We have also shown that the transcriptomes of tumor cells cocultured with CAFs can be altered by reversing the expression pattern of selected NRs, namely, PPARβ/δ, VDR, AR and retinoic acid receptor (RAR)-β receptor, to result in functional changes such as impaired invasiveness, reduced proliferation, and altered energy metabolism and redox response [15]. This evidence concerns the gene VDR and neoplasm.