Chung-Hsien Chou BS et al. showed that concordant up-regulation of miR-31, miR-96, and miR-182 may increase migration and invasion of HNSCC cells by co-targeting NUMB mRNA [41], while Yan Guo et al. demonstrated the involvement of miR-96 in the Tongue Cancer tumorigenesis by promoting the repression of MTSS1 mRNA expression [42]. Here, NUMB is linked to tongue cancer.