Age, body mass index (BMI), weeks on hemodialysis, frequency of hemodialysis, dialysis solution temperature, diabetes mellitus Type 2, family history of RLS, smoking, tea intake, coffee intake and other routine laboratory blood test data including creatinine, albumin, alkaline phosphatase (AKP), calcium, phosphate, hemoglobin, ferritin, transferrin, total iron binding capacity (TIBC), parathyroid hormone (PTH), URR, and Kt/v, showed no relationship with RLS (P Value > 0.05). The gene discussed is ALB; the disease is type 2 diabetes mellitus.