HDAC6 and pulmonary arterial hypertension: In the pulmonary artery smooth muscle cells (PASMCs) of patients with pulmonary arterial hypertension (PAH), HDAC6 expression level was significantly upregulated, and inhibition of HDAC6 could reduce PASMC proliferation and resistance to apoptosis and finally improve established PAH (Boucherat et al., 2017).