At the same time, we would like to point out that PGK1 may also affect endometrial cancer chemoresistance in HSP90-independent manners, including by regulating autophagy, glycolysis, or the tricarboxylic acid (TCA) cycle (Ariosa & Klionsky, 2017; Li et al., 2016; Qian et al., 2017a; Qian et al., 2017b). Here, PGK1 is linked to endometrial cancer.