RHOA and neoplasm: It was observed that RhoA signaling cascade plays an essential role in the migration ability of hMSCs [8], particularly in hypoxic conditions in which upregulation of hypoxia inducible factor-1 (HIF-1α) and activated GTP-bound RhoA were found, highlighting a strong link between them in hMSC [10,11] and in tumor cells [12,13,14].