With a direct relevance to the current study, in a ligature and Porphyromonas gingivalis induced periodontitis model in rats, baicalin reduced alveolar bone loss, levels of HMGB1, TNF-α, and IL-1β significantly, in References [11,12]; in a similar model, baicalin prevented alveolar bone loss, and maintained high area fraction of collagen fiber through significant reductions in the expression of COX-2 and inducible nitric oxide synthase [13], as well as inhibition of expression of MMP-1 and MMP-9 [14]. This evidence concerns the gene TNF and periodontitis.