Promoting the human periodontal ligament cell growth and differentiation [15], inhibiting IL-1 beta-induced synthesis of PGE2 and LTB4 and enhancing collagen synthesis in human gingival fibroblast [16], downregulating IL-6 and IL-8 expression in human oral keratinocytes [17], decreasing receptor activator of nuclear factor-κB ligand (RANKL) mRNA in cultured human periodontal ligament cells [18] are some of the significant activities of baicalin indicative of its usage in periodontal disease. This evidence concerns the gene IL6 and periodontal disorder.