UP446, a botanical composition which consists primarily of baicalin from the root of Scutellaria baicalensis Georgi and catechin from the heartwood of Acacia catechu, possesses in vitro activities with potential benefits in periodontal disease such as inhibition of COX and LOX enzymes [23] and down regulation of COX-2, TNF-α, IL-1β, IL-6, and NF-κB gene expression [24]. The gene discussed is TNF; the disease is periodontal disorder.