Interestingly, our panel included genes already described to be cancer predisposition genes (FAS, ITK, KIF1B, PGR and MET) or previously reported as playing important roles in cancer (ABI1, ARID5B, DNMT3A, HEY1, KDM5C, NCOA1, NUP98, and SLC34A2), or in DNA repair process (FANCF) [29,30,31,32,33,34]. The gene discussed is DNMT3A; the disease is cancer.