The genotype frequencies of IL-18 -656 (A/C, rs1946519), -607 (A/C, rs1946518), and -137 (G/C, rs187238) for the 92 patients with RCC and the 580 age- and gender-matched healthy control subjects were determined, and the comparative results of codominant, dominant, and recessive models are presented in Table 2. This evidence concerns the gene IL18 and renal cell carcinoma.