In detail, the stratification of RCC patients and non-cancer subjects according to personal behavior revealed that IL-18 -607 genotypes may play a significant role in the determination of susceptibility to RCC in non-smokers (Figure 1), non-alcohol drinkers (Figure 2), those with and without hypertension (Figure 3), and those without diabetes (Figure 4), but not in smokers, alcohol drinkers, or those with diabetes (Figure 1, Figure 3 and Figure 4). This evidence concerns the gene IL18 and cancer.