In this context, it should be noted that the NK cell-mediated killing of melanoma cells is controlled by multiple activating receptors/ligands [10,16,17,18], among which the NKG2D receptor/NKG2D ligand interaction plays an important role and induces one of the most important signals leading to the lysis of melanoma tumor cells [9,19]. Here, KLRK1 is linked to neoplasm.