Rats on HFD with chronic inflammation developed severe renal degeneration and glomerular damage, indicating that the aggravation of obesity may itself exacerbate existing kidney damage, perhaps due to the overexpression of CD36, TNFα, IL-6, and monocyte chemotactic protein-1 (MCP-1) during inflammation, which results in the thickening of the glomerular basement membrane, extracellular matrix, glomerulosclerosis [34]. Here, CD36 is linked to obesity due to melanocortin 4 receptor deficiency.