Interestingly, as compared to the commercial EGFR-targeted drugs, the SI of gefitinib (SI = 0.81) and osimertinib (SI = 1.15) toward A549 NSCLC and normal human bronchial epithelial (HBE) cell lines is much lower than MG3 (2.48, Figure 2H) [46]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.