Taken together, the proposed underlying mechanisms of MG3 against two NSCLC cell lines are illustrated in Figure 4E showing that MG3 inhibited downstream activity of STAT3 and Akt without interfering phosphorylation of EGFR, whilst the phosphorylation of Erk was significantly enhanced upon MG3 treatments. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.