Taken together, the proposed underlying mechanisms of MG3 against two NSCLC cell lines are illustrated in Figure 4E showing that MG3 inhibited downstream activity of STAT3 and Akt without interfering phosphorylation of EGFR, whilst the phosphorylation of Erk was significantly enhanced upon MG3 treatments. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.