EDN1 and pulmonary fibrosis: Nonetheless, as studies have demonstrated the mutual regulation and collaboration between TGF-β1 and ET-1 in the development of pulmonary fibrosis [26], the current data does not imply the superiority of ET-1 over TGF-β1 in the modulation of pleural fibrogenesis, but features the importance of ET-1 in TBPE.