RASD2 and nervous system disorder: In addition to its striatum (STR) enrichment [2,3,4,5,6], Rhes mRNA is also localised in cortical and midbrain regions of rodents and primates [7,8], and modulates striatal dopamine (DA) and adenosine-related signal transduction and behaviours [2,3,4,5,9], further confirming its modulatory role in psychiatric and neurological diseases in which DA is involved.