Furthermore, 17 genes (ACTG1, AK1, AKT2, BRD2, CD4, CRYAA, FAM83H, GNB3, LOC403555, MIR221, MIR338, SCN2B, SGSH, TIMP1, TNNT2, TPI1, and USP11) were covered by CNAs in both PIA, and more than 20% of PC cases (≥3 cases). The gene discussed is TPI1; the disease is pachyonychia congenita.