PTEN and cancer: The concomitant presence of prostatic intraepithelial neoplasia, proliferative inflammatory atrophy (PIA), and bone metastases as well as the deregulation of cancer-related transcripts/proteins, including MDM2, PTEN, TP53, CTNNB1, and CDH1, are common events in dog and human PCs [10,11,15,16,17].