APOE and atherosclerosis: On the contrary, trehalose influenced neither the progression of atherosclerosis (“cross section”: 271325.4 ± 7225.5 μm2 vs 275830.8 ± 12676.9 μm2; p > 0.05) (Figure 2G,H,I) nor the content of macrophages (CD68 staining: 45.25% ± 1.7% vs 45.52% ± 3.4%; p < 0.05) (Figure 3D,E,F) in apoE−/− mice fed an HFD.