Trehalose caused a significant decrease of atherosclerotic lesions by almost 40% in the aorta of apoE−/− mice fed a CD as measured by the en face method (11.5 ± 0.9% vs 15.8 ± 1.2%; p < 0.05) (Figure 2A,B,C) and atherosclerosis evaluation at the aortic sinus (40118 ± 3904 μm2 vs 71492 ± 10703 μm2; p < 0.05) (Figure 2D,E,F). The gene discussed is APOE; the disease is atherosclerosis.