APOE and fatty liver disease: The apoE−/− mice are considered a versatile model to study the variability of the anti-atherosclerotic action of a given substance, as the development of atherosclerotic plaques and hepatic steatosis in these animals varies depending on age, sex, and diet and is the least severe in male mice on a chow diet and the most severe in female mice on a high-fat diet [23,24,25].