In addition, it was observed that trehalose supplementation can have also other advantageous effects in metabolic diseases: it mitigated insulin resistance, suppressed mesenteric adipocyte hypertrophy, increased the plasma level of adiponectin in obese mice, and reduced hepatic endoplasmic reticulum stress in old mice [16,29,30,31]. The gene discussed is ADIPOQ; the disease is Other metabolic disease.