The expression level of lncRNA MALAT1 was upregulated in acute myeloid leukemia, and MALAT1 knockdown in lung cancer cells led to upregulation of miR-101-3p expression, and then miR-101-3p reduced myeloid cell leukemia 1 (MCL1) expression by binding to 3’-UTR. This evidence concerns the gene MALAT1 and acute myeloid leukemia.