Similarly, Pinkney et al. reported negative associations between SHBG, BMI, and fasting insulin in a longitudinal study of 347 children from age 5 to 15 years (3), and Glueck et al. showed that low SHBG levels in girls at the age of 14 predicted development of metabolic syndrome 10 years later (30). The gene discussed is SHBG; the disease is metabolic syndrome.