CD4 and cancer: A cut-off of T cell frequency below 51.9% for CD4+CD45RChigh (sensibility 84.0%, specificity 54.7%, positive predictive value 42.0%, negative predictive value 89.8%, Fig 1B) and 48.6% for CD8+CD45RChigh appeared as the best thresholds for cancer prediction (sensibility 68.0%, specificity 50.0%, positive predictive value 41.0%, negative predictive value 75.0%).