TLR2 and viral infectious disease: Toll‐like receptors (TLRs) are central players in the early host immune response to acute viral infection and have been shown to play a crucial role in defense against microorganisms.3 Evidences have demonstrated that the activation of TLR signaling pathway by HBV was able to inhibit HBV replication.6, 12 Thompson et al13 documented that TLR2 inhibited HBV replication in hepatoma cell lines in vitro.