MAPT and Alzheimer disease: Five of these variants were previously reported as associated with AD and include missense mutations in PSEN1 (rs63749824/p.A75V [n = 7]29; rs63750592/p.R35Q [n = 4]),30SORL1 (rs139710266/p.Y391C [n = 5]),31 and MAPT (rs63750424/p.R741W [n = 4]),32 and a stop-gain mutation in ABCA7 (rs145987355/ p.E1679X [n = 4]).33 Genome-wide, 24 variants in 19 genes with moderate to high functional impact were observed in 10 or more participants with AD but absent in controls (eTable 8 in the Supplement).