Gene-set enrichment analysis revealed that the network genes were significantly enriched in the Notch signaling pathway (P = 6.48 × 10−49), angiogenesis (P = 1.61 × 10−12), and 2 AD-related pathways involving secretase-mediated amyloid precursor protein cleavage (P = 3.50 × 10−16) and presenilin γ-secretase complex (P = 5.78 × 10−26) (Table 2). The gene discussed is APP; the disease is Alzheimer disease.