Furthermore, unlike the TREM2 R47H mutation and rare coding variants at other loci that have been associated with AD,4,5,6,7,8 the NOTCH3rs149307620 and TREM2 Q33X mutations appear to be fully penetrant among persons surviving to late age, which perhaps would be the first examples of causative mutations for late-onset AD. This evidence concerns the gene TREM2 and Alzheimer disease.