To further explore the biological functions and pathways for NOTCH3 in AD, a high-confidence protein-protein interaction network was constructed including NOTCH3 and JAG1. The resulting 30-gene interaction network contains several AD-related genes, including BACE1, PSEN1, PSEN2, and APP (eFigure 6 in the Supplement). The gene discussed is PSEN2; the disease is Alzheimer disease.