For example, the most common RCC histology, clear cell renal cell carcinoma (ccRCC), is characterized by biallelic loss of the von Hippel-Lindau (VHL) tumor suppressor and subsequent activation of hypoxia inducible factor (HIF), suppressing mitochondrial respiration in favor of glycolytic metabolism. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.