≤4.0 mmol/L (≤72 mg/dL) or severe hypoglycaemia (requiring assistance) and BG <3.1 mmol/L (<56 mg/dL) or recovery following carbohydrate administration.Nocturnal hypoglycaemia defined as events occurring after bedtime insulin dose and before breakfast/morning SMBG or administration of glucose‐lowering agent. The gene discussed is INS; the disease is Hypoglycemia.