INS and Hypoglycemia: Although the BEGIN and EDITION trials typically used the same titration algorithm for control and experimental insulins within each trial, the BEGIN trials utilized a titration algorithm with larger dose adjustments than that utilized in the EDITION trials (Figure 1), which may have affected the incidence and prevalence of hypoglycaemia events during the titration period of the former.12, 13, 14, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31