PLK1 and central nervous system cancer: Polo‐like kinase 1 (PLK1) is a serine/threonine protein kinase that is known to be a key regulator of mitosis, with critical roles in cell cycle‐associated processes.25, 26 PLK1 is involved in the regulation of the cell cycle and the growth of various tumors, including breast cancer, renal cell cancer, and prostate cancer.18, 27, 28 Two studies found some lncRNAs, such as Hox transcript antisense RNA (HOTAIR) and lnc‐RI, exerted their regulatory effects through PLK131, 32; however, such lncRNA‐PLK1 associated approach has not yet been observed in glioma cells.