There are a lot of studies that revealed the causative genes to nonsyndromic cleft lip palate (NSCLP) formation such as TGF family, FGF family, cleft lip, and palate have been associated transmembrane protein 1 (CLPTM1), special AT‐rich sequence‐binding protein 2 (SATB2), and small ubiquitin‐like modifier 1 (SUMO1) and IRF6 (Carter et al., 2010; Nie, Luukko, & Kettunen, 2006; Pauws & Stanier, 2007; Scapoli et al., 2005). This evidence concerns the gene SUMO1 and cleft lip.