The finding that a higher HIV viral load, regardless cART or CD4 cell count was independently associated with an increased risk of new TB infection, is consistent with a previous study in Spain, suggesting that a high HIV viral load in treatment‐naïve patients, in patients with treatment interruption or even in treatment‐experienced patients with a failing antiretroviral regimen may be linked to an increased occurrence of active TB 20. The gene discussed is CD4; the disease is tuberculosis.