SOCS3 and tuberculosis: For instance, a research by Fu et al uncovered that suppressor of cytokine signaling 3 (SOCS3), which is an essential negative regulator of cytokine defense to Mycobacterium tuberculosis invasion and its nearby lncRNA XLOC_012582, was overexpressed in B cells from active TB patients.31 On the other hand, there are limited data support the association between lncRNA genetic polymorphisms and susceptibility and phenotypes of TB.