Cytokines such as CC chemokine, a protein belonging to the CXC chemokine family called stromal‐derived factor 1, and vascular endothelial growth factor attract TAMs into the tumor microenvironment.32 TAMs support cancer progression by secreting a variety of growth factors.33 IL‐10 secreted from TAMs contributes to establishment of the immunosuppressive tumor microenvironment by preventing dendritic cell‐mediated antitumor immune responses.34 Peranzoni et al35 reported that macrophages inhibit CD8+ tumor‐infiltrating lymphocytes (TIL). This evidence concerns the gene CD8A and cancer.