In the SONs of Gi DREADD rats, CNO pretreatment significantly reduced Fos staining associated with 3% HTN as compared to CTRL + CNO + 3% HTN rats (p = 0.012, Tukey’s post hoc analysis) but did not reduce the staining to control levels (vs CTRL + VEH + 0.9% SAL, p < 0.001; vs CTRL + CNO + 0.9% SAL, p < 0.001). This evidence concerns the gene FOS and hypertensive disorder.