FOS and hypertensive disorder: For the remaining regions (OVLT, PVN, PVT, and RVLM) Fos staining associated with CNO and 3% HTN was not different between the CTRL virus and Gi DREADD-injected rats and both of these groups were significantly increased as compared to the two CTRL groups that received the 0.9% SAL injection (Fig. 9A,B).