IL6 and infection: For example, an infection only during the first trimester was associated with a 8% lower level of IL-6 (95% CI -25, 14%), whereas an infection only during the 2nd or third trimester was associated with a 7% lower level of IL-6 (95% CI, − 15,3%) and an infection in the first trimester and later in pregnancy was associated with 29% lower level of IL-6 (95% CI -49,0%) Adjustments for other prenatal factors did not significantly affect the estimates.