The incidence of NAC involvement among patients with breast carcinoma who underwent mastectomy and axillary clearance was associated with certain important factors, such as the tumour size, the distance from the tumour site to the edge of the areola, lymph node metastasis, lymphovascular invasion, HER overexpression, and ER and PR negativity. Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.