INS and type 2 diabetes mellitus: The polymorphism rs1801282 (c.34C > G) on codon 12 of exon B of the PPAR-γ2 gene, which leads to the substitution of proline with alanine (Pro12Ala), was found to be associated with higher insulin sensitivity, lower body mass index (BMI), decreased risk of T2DM and diabetic nephropathy [28–32].