Although the mentioned investigations revealed that PPARγ gene polymorphism was significantly associated with NAFLD in some population, Dongiovanni et al. observed that the PPAR-γ2 Pro12Ala frequency was not significantly different between NAFLD patients and healthy controls, in a study enrolling 202 Italian patients and 346 matched controls [12]. Here, PPARG is linked to metabolic dysfunction-associated steatotic liver disease.