MTOR and autoimmune polyendocrinopathy: We observed that anti-β2-GPI IgG from APS patients or starvation (HBSS) caused significant reduction in phospho-mTOR compared to untreated cells or to monocytes stimulated with control human serum IgG, p < 0.001 (no change was detected in the levels of total mTOR) (Supplementary Figure 1).