Since in a previous work we detected increased serum levels of HMGB1 in subjects affected by pregnancy morbidity, as well as in a small group of patients with APS (21), in this investigation we wanted to extend the data evaluating serum levels of HMGB1/soluble RAGE (sRAGE) in patients with APS and their possible correlation with clinical manifestations. Here, AGER is linked to autoimmune polyendocrinopathy.